eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cone rod dystrophy |
| Symptom | C1998028|photoreceptor degeneration |
| Sentences | 6 |
| PubMedID- 24705452 | Importantly, in the present study, by challenging the retina with moderate light, we demonstrate that ushstat vector rescues the light induced retinal degeneration phenotype in shaker1 mice, which suggests that this therapy might protect against light dependent photoreceptor degeneration associated with retinitis pigmentosa in ush1b individuals. |
| PubMedID- 24142887 | Recent evidence shows that ccr2+ monocyte recruitment also plays an important role in photoreceptor degeneration in models of retinitis pigmentosa (guo et al, 2012), photo-oxidative stress (rutar et al, 2012; suzuki et al, 2012), and in the carboxyethylpyrrole-immunization induced model of amd (cruz-guilloty et al, 2013). |
| PubMedID- 26358772 | Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (rp2)-knockout mice by gene replacement therapy. |
| PubMedID- 23691278 | In retinitis pigmentosa (rp) leading to photoreceptor degeneration, the elm, is/os, and cost lines are shortened with the progression of the disease. |
| PubMedID- 24174679 | These results reveal that rip kinase-mediated necrosis strongly contributes to cone and rod degeneration in irbp(-/-) mice, implicating the tnf-rip pathway as a potential therapeutic target to prevent or delay photoreceptor degeneration in patients with retinitis pigmentosa caused by irbp mutation. |
| PubMedID- 20720224 | Purpose: since 2002, six blind patients have undergone implantation of an epiretinal 4 x 4 electrode array designed to directly stimulate the remaining cells of the retina after severe photoreceptor degeneration due to retinitis pigmentosa. |
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